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BMCBI
2008
145views more  BMCBI 2008»
13 years 8 months ago
The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction
Background: Amino acids responsible for structure, core function or specificity may be inferred from multiple protein sequence alignments where a limited set of residue types are ...
Jonathan R. Manning, Emily R. Jefferson, Geoffrey ...
BMCBI
2008
110views more  BMCBI 2008»
13 years 8 months ago
Predikin and PredikinDB: a computational framework for the prediction of protein kinase peptide specificity and an associated da
Background: We have previously described an approach to predicting the substrate specificity of serine-threonine protein kinases. The method, named Predikin, identifies key conser...
Neil F. W. Saunders, Ross I. Brinkworth, Thomas Hu...
BMCBI
2008
99views more  BMCBI 2008»
13 years 8 months ago
CWRML: representing crop wild relative conservation and use data in XML
Background: Crop wild relatives are wild species that are closely related to crops. They are valuable as potential gene donors for crop improvement and may help to ensure food sec...
Jonathan D. Moore, Shelagh P. Kell, Jose M. Iriond...
BMCBI
2008
164views more  BMCBI 2008»
13 years 8 months ago
Word correlation matrices for protein sequence analysis and remote homology detection
Background: Classification of protein sequences is a central problem in computational biology. Currently, among computational methods discriminative kernel-based approaches provid...
Thomas Lingner, Peter Meinicke
BMCBI
2008
160views more  BMCBI 2008»
13 years 8 months ago
Dynamic sensitivity analysis of biological systems
Background: A mathematical model to understand, predict, control, or even design a real biological system is a central theme in systems biology. A dynamic biological system is alw...
Wu Hsiung Wu, Feng Sheng Wang, Maw Shang Chang