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BMCBI
2010
90views more  BMCBI 2010»
13 years 11 months ago
Local alignment of generalized k-base encoded DNA sequence
Background: DNA sequence comparison is a well-studied problem, in which two DNA sequences are compared using a weighted edit distance. Recent DNA sequencing technologies however o...
Nils Homer, Stanley F. Nelson, Barry Merriman
BMCBI
2010
115views more  BMCBI 2010»
13 years 11 months ago
Multiconstrained gene clustering based on generalized projections
Background: Gene clustering for annotating gene functions is one of the fundamental issues in bioinformatics. The best clustering solution is often regularized by multiple constra...
Jia Zeng, Shanfeng Zhu, Alan Wee-Chung Liew, Hong ...
BMCBI
2010
208views more  BMCBI 2010»
13 years 11 months ago
Using machine learning to speed up manual image annotation: application to a 3D imaging protocol for measuring single cell gene
Background: Image analysis is an essential component in many biological experiments that study gene expression, cell cycle progression, and protein localization. A protocol for tr...
Zafer Aydin, John I. Murray, Robert H. Waterston, ...
BMCBI
2010
152views more  BMCBI 2010»
13 years 11 months ago
A high-throughput de novo sequencing approach for shotgun proteomics using high-resolution tandem mass spectrometry
Background: High-resolution tandem mass spectra can now be readily acquired with hybrid instruments, such as LTQ-Orbitrap and LTQ-FT, in high-throughput shotgun proteomics workflo...
Chongle Pan, Byung-Hoon Park, William H. McDonald,...
BMCBI
2010
115views more  BMCBI 2010»
13 years 11 months ago
Integration of multiple data sources to prioritize candidate genes using discounted rating system
Background: Identifying disease gene from a list of candidate genes is an important task in bioinformatics. The main strategy is to prioritize candidate genes based on their simil...
Yongjin Li, Jagdish Chandra Patra
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