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BMCBI
2008
123views more  BMCBI 2008»
13 years 10 months ago
A tree-based conservation scoring method for short linear motifs in multiple alignments of protein sequences
Background: The structure of many eukaryotic cell regulatory proteins is highly modular. They are assembled from globular domains, segments of natively disordered polypeptides and...
Claudia Chica, Alberto Labarga, Cathryn M. Gould, ...
BIB
2006
141views more  BIB 2006»
13 years 10 months ago
Statistical significance in biological sequence analysis
One of the major goals of computational sequence analysis is to find sequence similarities, which could serve as evidence of structural and functional conservation, as well as of ...
Alexander Yu. Mitrophanov, Mark Borodovsky
WABI
2009
Springer
109views Bioinformatics» more  WABI 2009»
14 years 4 months ago
Fast Prediction of RNA-RNA Interaction
Regulatory antisense RNAs are a class of ncRNAs that regulate gene expression by prohibiting the translation of an mRNA by establishing stable interactions with a target sequence. ...
Raheleh Salari, Rolf Backofen, Süleyman Cenk ...
ISMB
1997
13 years 11 months ago
Standardized Representations of the Literature: Combining Diverse Sources of Ribosomal Data
We are building a knowledge base (KB) of published structural data on the 30s ribosomal subunit in prokaryotes. Our KB is distinguished by a standardized representation of biologi...
Russ B. Altman, Neil F. Abernethy, Richard O. Chen
BMCBI
2006
117views more  BMCBI 2006»
13 years 10 months ago
Incorporating background frequency improves entropy-based residue conservation measures
Background: Several entropy-based methods have been developed for scoring sequence conservation in protein multiple sequence alignments. High scoring amino acid positions may corr...
Kai Wang, Ram Samudrala