Multiple sequence alignment is a fundamental and very computationally intensive task in molecular biology. MUSCLE, a new algorithm for creating multiple alignments of protein sequ...
We describe a novel method for detecting the domain structure of a protein from sequence information alone. The method is based on analyzing multiple sequence alignments that are ...
Background: Frameshift mutations in protein-coding DNA sequences produce a drastic change in the resulting protein sequence, which prevents classic protein alignment methods from ...
The GeneTrees phylogenomics system pursues comparative genomic analyses from the perspective of gene phylogenies for individual genes. The GeneTrees project has the goal of provid...
Abstract-- The trans-genomic query (TGQ) problem -- enabling the free query of biological information, even across genomes -- is a central challenge facing bioinformatics. Solution...
Douglas Stott Parker Jr., Ruey-Lung Hsiao, Yi Xing...