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BMCBI
2005
102views more  BMCBI 2005»
13 years 10 months ago
Genome-wide identification of the regulatory targets of a transcription factor using biochemical characterization and computatio
Background: A major challenge in computational genomics is the development of methodologies that allow accurate genome-wide prediction of the regulatory targets of a transcription...
Emmitt R. Jolly, Chen-Shan Chin, Ira Herskowitz, H...
BMCBI
2010
135views more  BMCBI 2010»
13 years 10 months ago
Lists2Networks: Integrated analysis of gene/protein lists
Background: Systems biologists are faced with the difficultly of analyzing results from large-scale studies that profile the activity of many genes, RNAs and proteins, applied in ...
Alexander Lachmann, Avi Ma'ayan
SIAMJO
2010
127views more  SIAMJO 2010»
13 years 4 months ago
Trace Norm Regularization: Reformulations, Algorithms, and Multi-Task Learning
We consider a recently proposed optimization formulation of multi-task learning based on trace norm regularized least squares. While this problem may be formulated as a semidefini...
Ting Kei Pong, Paul Tseng, Shuiwang Ji, Jieping Ye
BMCBI
2006
118views more  BMCBI 2006»
13 years 10 months ago
Microarray image analysis: background estimation using quantile and morphological filters
Background: In a microarray experiment the difference in expression between genes on the same slide is up to 103 fold or more. At low expression, even a small error in the estimat...
Anders Bengtsson, Henrik Bengtsson
BMCBI
2006
169views more  BMCBI 2006»
13 years 10 months ago
Beyond microarrays: Finding key transcription factors controlling signal transduction pathways
Background: Massive gene expression changes in different cellular states measured by microarrays, in fact, reflect just an "echo" of real molecular processes in the cell...
Alexander E. Kel, Nico Voss, Ruy Jauregui, Olga V....