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BIOINFORMATICS
2008
172views more  BIOINFORMATICS 2008»
13 years 10 months ago
Fitting a geometric graph to a protein-protein interaction network
Motivation: Finding a good network null model for protein-protein interaction (PPI) networks is a fundamental issue. Such a model would provide insights into the interplay between...
Desmond J. Higham, Marija Rasajski, Natasa Przulj
BMCBI
2010
178views more  BMCBI 2010»
13 years 10 months ago
Selecting high-dimensional mixed graphical models using minimal AIC or BIC forests
Background: Chow and Liu showed that the maximum likelihood tree for multivariate discrete distributions may be found using a maximum weight spanning tree algorithm, for example K...
David Edwards, Gabriel C. G. de Abreu, Rodrigo Lab...
BMCBI
2010
133views more  BMCBI 2010»
13 years 10 months ago
Consolidating metabolite identifiers to enable contextual and multi-platform metabolomics data analysis
Background: Analysis of data from high-throughput experiments depends on the availability of well-structured data that describe the assayed biomolecules. Procedures for obtaining ...
Henning Redestig, Miyako Kusano, Atsushi Fukushima...
BMCBI
2010
163views more  BMCBI 2010»
13 years 10 months ago
Reduced representation of protein structure: implications on efficiency and scope of detection of structural similarity
Background: Computational comparison of two protein structures is the starting point of many methods that build on existing knowledge, such as structure modeling (including modeli...
Zong Hong Zhang, Hwee Kuan Lee, Ivana Mihalek
BMCBI
2010
105views more  BMCBI 2010»
13 years 10 months ago
Evaluation of fecal mRNA reproducibility via a marginal transformed mixture modeling approach
Background: Developing and evaluating new technology that enables researchers to recover gene-expression levels of colonic cells from fecal samples could be key to a non-invasive ...
Nysia I. George, Joanne R. Lupton, Nancy D. Turner...