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» On Compressibility of Protein Sequences
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GECCO
2005
Springer
124views Optimization» more  GECCO 2005»
14 years 3 months ago
The evolutionary computation approach to motif discovery in biological sequences
Finding motifs — patterns of conserved residues — within nucleotide and protein sequences is a key part of understanding function and regulation within biological systems. Thi...
Michael A. Lones, Andrew M. Tyrrell
BMCBI
2008
100views more  BMCBI 2008»
13 years 10 months ago
Extracting transcription factor binding sites from unaligned gene sequences with statistical models
Background: Transcription factor binding sites (TFBSs) are crucial in the regulation of gene transcription. Recently, chromatin immunoprecipitation followed by cDNA microarray hyb...
Chung-Chin Lu, Wei-Hao Yuan, Te-Ming Chen
BMCBI
2010
86views more  BMCBI 2010»
13 years 10 months ago
Mining protein loops using a structural alphabet and statistical exceptionality
Background: Protein loops encompass 50% of protein residues in available three-dimensional structures. These regions are often involved in protein functions, e.g. binding site, ca...
Leslie Regad, Juliette Martin, Grégory Nuel...
BMCBI
2008
110views more  BMCBI 2008»
13 years 10 months ago
Predikin and PredikinDB: a computational framework for the prediction of protein kinase peptide specificity and an associated da
Background: We have previously described an approach to predicting the substrate specificity of serine-threonine protein kinases. The method, named Predikin, identifies key conser...
Neil F. W. Saunders, Ross I. Brinkworth, Thomas Hu...
BMCBI
2006
102views more  BMCBI 2006»
13 years 10 months ago
Protein secondary structure prediction for a single-sequence using hidden semi-Markov models
Background: The accuracy of protein secondary structure prediction has been improving steadily towards the 88% estimated theoretical limit. There are two types of prediction algor...
Zafer Aydin, Yucel Altunbasak, Mark Borodovsky