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133
Voted
BMCBI
2008
15 years 3 months ago
2008
Motivation: In the last years more than 20 vertebrate genomes have been sequenced, and the rate at which genomic DNA information becomes available is rapidly accelerating. Gene du...
117
Voted
BMCBI
2008
2008
RPPAML/RIMS: A metadata format and an information management system for reverse phase protein arrays
15 years 3 months ago
Background: Reverse Phase Protein Arrays (RPPA) are convenient assay platforms to investigate the presence of biomarkers in tissue lysates. As with other high-throughput technolog...
130
Voted
BMCBI
2006
15 years 3 months ago
2006
Background: Simulation of DNA-microarray data serves at least three purposes: (i) optimizing the design of an intended DNA microarray experiment, (ii) comparing existing pre-proce...
150
Voted
BMCBI
2006
15 years 3 months ago
2006
Background: The incorporation of statistical models that account for experimental variability provides a necessary framework for the interpretation of microarray data. A robust ex...
157
Voted
BMCBI
2006
15 years 3 months ago
2006
Background: Comparison of large protein datasets has become a standard task in bioinformatics. Typically researchers wish to know whether one group of proteins is significantly en...