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» On subdomains: Testing, profiles, and components
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BMCBI
2008
115views more  BMCBI 2008»
13 years 10 months ago
Principal components analysis based methodology to identify differentially expressed genes in time-course microarray data
Background: Time-course microarray experiments are being increasingly used to characterize dynamic biological processes. In these experiments, the goal is to identify genes differ...
Sudhakar Jonnalagadda, Rajagopalan Srinivasan
BMCBI
2008
135views more  BMCBI 2008»
13 years 10 months ago
Knowledge-guided multi-scale independent component analysis for biomarker identification
Background: Many statistical methods have been proposed to identify disease biomarkers from gene expression profiles. However, from gene expression profile data alone, statistical...
Li Chen, Jianhua Xuan, Chen Wang, Ie-Ming Shih, Yu...
BMCBI
2008
145views more  BMCBI 2008»
13 years 10 months ago
Mapping gene expression quantitative trait loci by singular value decomposition and independent component analysis
Background: The combination of gene expression profiling with linkage analysis has become a powerful paradigm for mapping gene expression quantitative trait loci (eQTL). To date, ...
Shameek Biswas, John D. Storey, Joshua M. Akey
WWW
2003
ACM
14 years 10 months ago
SHOCK: communicating with computational messages and automatic private profiles
A computationally enhanced message contains some embedded programmatic components that are interpreted and executed automatically upon receipt. Unlike ordinary text email or insta...
Rajan M. Lukose, Eytan Adar, Joshua R. Tyler, Caes...
BMCBI
2005
152views more  BMCBI 2005»
13 years 9 months ago
Improved profile HMM performance by assessment of critical algorithmic features in SAM and HMMER
Background: Profile hidden Markov model (HMM) techniques are among the most powerful methods for protein homology detection. Yet, the critical features for successful modelling ar...
Markus Wistrand, Erik L. L. Sonnhammer