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» On the Approximability of Comparing Genomes with Duplicates
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TODS
2002
92views more  TODS 2002»
13 years 7 months ago
Searching in metric spaces with user-defined and approximate distances
Metric access methods (MAMs), such as the M-tree, are powerful index structures for supporting ty queries on metric spaces, which represent a common abstraction for those searchin...
Paolo Ciaccia, Marco Patella
BMCBI
2010
113views more  BMCBI 2010»
13 years 7 months ago
A classification model for distinguishing copy number variants from cancer-related alterations
Background: Both somatic copy number alterations (CNAs) and germline copy number variants (CNVs) that are prevalent in healthy individuals can appear as recurrent changes in compa...
Irina Ostrovnaya, Gouri Nanjangud, Adam B. Olshen
BMCBI
2005
131views more  BMCBI 2005»
13 years 7 months ago
Functional annotation by identification of local surface similarities: a novel tool for structural genomics
Background: Protein function is often dependent on subsets of solvent-exposed residues that may exist in a similar three-dimensional configuration in non homologous proteins thus ...
Fabrizio Ferrè, Gabriele Ausiello, Andreas ...
BMCBI
2005
198views more  BMCBI 2005»
13 years 7 months ago
Clustering protein sequences with a novel metric transformed from sequence similarity scores and sequence alignments with neural
Background: The sequencing of the human genome has enabled us to access a comprehensive list of genes (both experimental and predicted) for further analysis. While a majority of t...
Qicheng Ma, Gung-Wei Chirn, Richard Cai, Joseph D....
CPM
1999
Springer
129views Combinatorics» more  CPM 1999»
13 years 12 months ago
On the Structure of Syntenic Distance
This paper examines some of the rich structure of the syntenic distance model of evolutionary distance, introduced by Ferretti et al. (1996). The syntenic distance between two gen...
David Liben-Nowell