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» On the Approximability of Comparing Genomes with Duplicates
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FCCM
2011
IEEE
311views VLSI» more  FCCM 2011»
12 years 11 months ago
String Matching in Hardware Using the FM-Index
—String matching is a ubiquitous problem that arises in a wide range of applications in computing, e.g., packet routing, intrusion detection, web querying, and genome analysis. D...
Edward Fernandez, Walid Najjar, Stefano Lonardi
RECOMB
2001
Springer
14 years 7 months ago
Applications of generalized pair hidden Markov models to alignment and gene finding problems
Hidden Markov models (HMMs) have been successfully applied to a variety of problems in molecular biology, ranging from alignment problems to gene nding and annotation. Alignment p...
Lior Pachter, Marina Alexandersson, Simon Cawley
JCSS
2008
80views more  JCSS 2008»
13 years 7 months ago
Improved bounds on sorting by length-weighted reversals
We study the problem of sorting binary sequences and permutations by length-weighted reversals. We consider a wide class of cost functions, namely f( ) = for all 0, where is the...
Michael A. Bender, Dongdong Ge, Simai He, Haodong ...
BMCBI
2005
158views more  BMCBI 2005»
13 years 7 months ago
Automated generation of heuristics for biological sequence comparison
Background: Exhaustive methods of sequence alignment are accurate but slow, whereas heuristic approaches run quickly, but their complexity makes them more difficult to implement. ...
Guy St. C. Slater, Ewan Birney
IJIT
2004
13 years 9 months ago
Computing Entropy for Ortholog Detection
Abstract-- Biological sequences from different species are called orthologs if they evolved from a sequence of a common ancestor species and they have the same biological function....
Hsing-Kuo Pao, John Case