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» On the Complexity of Hardness Amplification
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BMCBI
2008
92views more  BMCBI 2008»
13 years 9 months ago
OpenMS - An open-source software framework for mass spectrometry
Background: Mass spectrometry is an essential analytical technique for high-throughput analysis in proteomics and metabolomics. The development of new separation techniques, preci...
Marc Sturm, Andreas Bertsch, Clemens Gröpl, A...
BMCBI
2010
91views more  BMCBI 2010»
13 years 9 months ago
Ranked retrieval of Computational Biology models
Background: The study of biological systems demands computational support. If targeting a biological problem, the reuse of existing computational models can save time and effort. ...
Ron Henkel, Lukas Endler, Andre Peters, Nicolas Le...
ASE
2006
110views more  ASE 2006»
13 years 9 months ago
Runtime recovery and manipulation of software architecture of component-based systems
Recently, more attention is paid to the researches and practices on how to use software architecture in software maintenance and evolution to reduce their complexity and cost. The ...
Gang Huang, Hong Mei, Fuqing Yang
BMCBI
2007
216views more  BMCBI 2007»
13 years 9 months ago
A replica exchange Monte Carlo algorithm for protein folding in the HP model
Background: The ab initio protein folding problem consists of predicting protein tertiary structure from a given amino acid sequence by minimizing an energy function; it is one of...
Chris Thachuk, Alena Shmygelska, Holger H. Hoos
MST
2006
149views more  MST 2006»
13 years 9 months ago
Parameterized Intractability of Distinguishing Substring Selection
A central question in computational biology is the design of genetic markers to distinguish between two given sets of (DNA) sequences. This question is formalized as the NP-comple...
Jens Gramm, Jiong Guo, Rolf Niedermeier