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BMCBI
2011
13 years 1 months ago
Elastic SCAD as a novel penalization method for SVM classification tasks in high-dimensional data
Background: Classification and variable selection play an important role in knowledge discovery in highdimensional data. Although Support Vector Machine (SVM) algorithms are among...
Natalia Becker, Grischa Toedt, Peter Lichter, Axel...
BMCBI
2011
13 years 1 months ago
Structator: fast index-based search for RNA sequence-structure patterns
Background: The secondary structure of RNA molecules is intimately related to their function and often more conserved than the sequence. Hence, the important task of searching dat...
Fernando Meyer, Stefan Kurtz, Rolf Backofen, Sebas...
BMCBI
2011
13 years 1 months ago
NeurphologyJ: an automatic neuronal morphology quantification method and its application in pharmacological discovery
Background: Automatic quantification of neuronal morphology from images of fluorescence microscopy plays an increasingly important role in high-content screenings. However, there ...
Shinn-Ying Ho, Chih-Yuan Chao, Hui-Ling Huang, Tza...
BMCBI
2011
13 years 1 months ago
Smith-Waterman Peak Alignment for Comprehensive Two-dimensional Gas Chromatography Mass Spectrometry
Background: Comprehensive two-dimensional gas chromatography coupled with mass spectrometry (GC × GCMS) is a powerful technique which has gained increasing attention over the las...
Seongho Kim, Imhoi Koo, Aiqin Fang, Xiang Zhang
BMCBI
2011
13 years 1 months ago
Study of large and highly stratified population datasets by combining iterative pruning principal component analysis and STRUCTU
Background: The ever increasing sizes of population genetic datasets pose great challenges for population structure analysis. The Tracy-Widom (TW) statistical test is widely used ...
Tulaya Limpiti, Apichart Intarapanich, Anunchai As...
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