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BMCBI
2010
136views more  BMCBI 2010»
13 years 8 months ago
Protein structure analysis of mutations causing inheritable diseases. An e-Science approach with life scientist friendly interfa
Background: Many newly detected point mutations are located in protein-coding regions of the human genome. Knowledge of their effects on the protein's 3D structure provides i...
Hanka Venselaar, Tim A. H. te Beek, Remko K. P. Ku...
BMCBI
2004
83views more  BMCBI 2004»
13 years 8 months ago
VKCDB: Voltage-gated potassium channel database
Background: The family of voltage-gated potassium channels comprises a functionally diverse group of membrane proteins. They help maintain and regulate the potassium ion-based com...
Bin Li, Warren J. Gallin
NAR
2002
98views more  NAR 2002»
13 years 8 months ago
Recent improvements to the SMART domain-based sequence annotation resource
SMART (Simple Modular Architecture Research Tool, http://smart.embl-heidelberg.de) is a web-based resource used for the annotation of protein domains and the analysis of domain ar...
Ivica Letunic, Leo Goodstadt, Nicholas J. Dickens,...
BMCBI
2005
190views more  BMCBI 2005»
13 years 8 months ago
Species-specific analysis of protein sequence motifs using mutual information
Background: Protein sequence motifs are by definition short fragments of conserved amino acids, often associated with a specific function. Accordingly protein sequence profiles de...
Jan Hummel, Nima Keshvari, Wolfram Weckwerth, Joac...
BMCBI
2010
167views more  BMCBI 2010»
13 years 8 months ago
Creating PWMs of transcription factors using 3D structure-based computation of protein-DNA free binding energies
Background: Knowledge of transcription factor-DNA binding patterns is crucial for understanding gene transcription. Numerous DNA-binding proteins are annotated as transcription fa...
Denitsa Alamanova, Philip Stegmaier, Alexander E. ...