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BMCBI
2011
13 years 3 months ago
Identifying hypermethylated CpG islands using a quantile regression model
Background: DNA methylation has been shown to play an important role in the silencing of tumor suppressor genes in various tumor types. In order to have a system-wide understandin...
Shuying Sun, Zhengyi Chen, Pearlly Yan, Yi-Wen Hua...
ECAI
2010
Springer
13 years 6 months ago
Describing the Result of a Classifier to the End-User: Geometric-based Sensitivity
This paper addresses the issue of supporting the end-user of a classifier, when it is used as a decision support system, to classify new cases. We consider several kinds of classif...
Isabelle Alvarez, Sophie Martin, Salma Mesmoudi
BMCBI
2010
155views more  BMCBI 2010»
13 years 8 months ago
A bi-ordering approach to linking gene expression with clinical annotations in gastric cancer
Background: In the study of cancer genomics, gene expression microarrays, which measure thousands of genes in a single assay, provide abundant information for the investigation of...
Fan Shi, Christopher Leckie, Geoff MacIntyre, Izha...
FLAIRS
2004
13 years 9 months ago
Gene Expression Data Classification with Revised Kernel Partial Least Squares Algorithm
One important feature of the gene expression data is that the number of genes M far exceeds the number of samples N. Standard statistical methods do not work well when N < M. D...
ZhenQiu Liu, Dechang Chen
BMCBI
2006
170views more  BMCBI 2006»
13 years 8 months ago
Biclustering of gene expression data by non-smooth non-negative matrix factorization
Background: The extended use of microarray technologies has enabled the generation and accumulation of gene expression datasets that contain expression levels of thousands of gene...
Pedro Carmona-Saez, Roberto D. Pascual-Marqui, Fra...