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BMCBI
2010
114views more  BMCBI 2010»
13 years 11 months ago
An integrative modular approach to systematically predict gene-phenotype associations
Background: Complex human diseases are often caused by multiple mutations, each of which contributes only a minor effect to the disease phenotype. To study the basis for these com...
Michael R. Mehan, Juan Nunez-Iglesias, Chao Dai, M...
BMCBI
2010
74views more  BMCBI 2010»
13 years 11 months ago
A weighted q-gram method for glycan structure classification
Background: Glycobiology pertains to the study of carbohydrate sugar chains, or glycans, in a particular cell or organism. Many computational approaches have been proposed for ana...
Limin Li, Wai-Ki Ching, Takako Yamaguchi, Kiyoko F...
BMCBI
2010
103views more  BMCBI 2010»
13 years 11 months ago
Virtual Screening of potential drug-like inhibitors against Lysine/DAP pathway of Mycobacterium tuberculosis
Background: An explosive global spreading of multidrug resistant Mycobacterium tuberculosis (Mtb) is a catastrophe, which demands an urgent need to design or develop novel/potent ...
Aarti Garg, Rupinder Tewari, Gajendra P. S. Raghav...
BMCBI
2010
95views more  BMCBI 2010»
13 years 11 months ago
Identifying main effects and epistatic interactions from large-scale SNP data via adaptive group Lasso
Background: Single nucleotide polymorphism (SNP) based association studies aim at identifying SNPs associated with phenotypes, for example, complex diseases. The associated SNPs m...
Can Yang, Xiang Wan, Qiang Yang, Hong Xue, Weichua...
BMCBI
2010
176views more  BMCBI 2010»
13 years 11 months ago
Reverse engineering gene regulatory network from microarray data using linear time-variant model
nd: Gene regulatory network is an abstract mapping of gene regulations in living cells that can help to predict the system behavior of living organisms. Such prediction capability...
Mitra Kabir, Nasimul Noman, Hitoshi Iba