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BIOINFORMATICS
2006
142views more  BIOINFORMATICS 2006»
13 years 8 months ago
Intervention in a family of Boolean networks
Motivation: Intervention in a gene regulatory network is used to avoid undesirable states, such as those associated with a disease. Several types of intervention have been studied...
Ashish Choudhary, Aniruddha Datta, Michael L. Bitt...
BMCBI
2006
123views more  BMCBI 2006»
13 years 8 months ago
Characterizing disease states from topological properties of transcriptional regulatory networks
Background: High throughput gene expression experiments yield large amounts of data that can augment our understanding of disease processes, in addition to classifying samples. He...
David Tuck, Harriet Kluger, Yuval Kluger
HEURISTICS
2008
124views more  HEURISTICS 2008»
13 years 8 months ago
A variable neighborhood search for the capacitated arc routing problem with intermediate facilities
In this talk we present a unified Variable Neighborhood Search (VNS) algorithm for the Capacitated Arc Routing Problem (CARP) and some of its variants - the Capacitated Arc Routin...
Michael Polacek, Karl F. Doerner, Richard F. Hartl...
BMCBI
2006
100views more  BMCBI 2006»
13 years 8 months ago
Using the nucleotide substitution rate matrix to detect horizontal gene transfer
Background: Horizontal gene transfer (HGT) has allowed bacteria to evolve many new capabilities. Because transferred genes perform many medically important functions, such as conf...
Micah Hamady, M. D. Betterton, Rob Knight
BMCBI
2006
137views more  BMCBI 2006»
13 years 8 months ago
Bounded search for de novo identification of degenerate cis-regulatory elements
Background: The identification of statistically overrepresented sequences in the upstream regions of coregulated genes should theoretically permit the identification of potential ...
Jonathan M. Carlson, Arijit Chakravarty, Radhika S...
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