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» Optimizing Complex Loss Functions in Structured Prediction
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GECCO
2000
Springer
138views Optimization» more  GECCO 2000»
14 years 20 days ago
Time Complexity of genetic algorithms on exponentially scaled problems
This paper gives a theoretical and empirical analysis of the time complexity of genetic algorithms (GAs) on problems with exponentially scaled building blocks. It is important to ...
Fernando G. Lobo, David E. Goldberg, Martin Pelika...
BMCBI
2010
159views more  BMCBI 2010»
13 years 9 months ago
Predicting domain-domain interaction based on domain profiles with feature selection and support vector machines
Background: Protein-protein interaction (PPI) plays essential roles in cellular functions. The cost, time and other limitations associated with the current experimental methods ha...
Alvaro J. González, Li Liao
UAI
2003
13 years 10 months ago
Bayesian Hierarchical Mixtures of Experts
The Hierarchical Mixture of Experts (HME) is a well-known tree-structured model for regression and classification, based on soft probabilistic splits of the input space. In its o...
Christopher M. Bishop, Markus Svensén
EUROGP
2005
Springer
14 years 2 months ago
Evolving L-Systems to Capture Protein Structure Native Conformations
Abstract. A protein is a linear chain of amino acids that folds into a unique functional structure, called its native state. In this state, proteins show repeated substructures lik...
Gabi Escuela, Gabriela Ochoa, Natalio Krasnogor
BIBM
2009
IEEE
206views Bioinformatics» more  BIBM 2009»
14 years 3 months ago
Application of Kernel Functions for Accurate Similarity Search in Large Chemical Databases
Background: Similaritysearch in chemical structure databases is an important problem with many applications in chemical genomics, drug design, and efficient chemical probe screeni...
Xiaohong Wang, Jun Huan, Aaron M. Smalter, Gerald ...