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BMCBI
2010
97views more  BMCBI 2010»
13 years 7 months ago
Biomarker discovery in heterogeneous tissue samples -taking the in-silico deconfounding approach
Background: For heterogeneous tissues, such as blood, measurements of gene expression are confounded by relative proportions of cell types involved. Conclusions have to rely on es...
Dirk Repsilber, Sabine Kern, Anna Telaar, Gerhard ...
JMLR
2006
79views more  JMLR 2006»
13 years 7 months ago
Estimation of Gradients and Coordinate Covariation in Classification
We introduce an algorithm that simultaneously estimates a classification function as well as its gradient in the supervised learning framework. The motivation for the algorithm is...
Sayan Mukherjee, Qiang Wu
GCB
2010
Springer
204views Biometrics» more  GCB 2010»
13 years 5 months ago
Learning Pathway-based Decision Rules to Classify Microarray Cancer Samples
: Despite recent advances in DNA chip technology current microarray gene expression studies are still affected by high noise levels, small sample sizes and large numbers of uninfor...
Enrico Glaab, Jonathan M. Garibaldi, Natalio Krasn...
CANDC
2005
ACM
13 years 7 months ago
Gene selection from microarray data for cancer classification - a machine learning approach
A DNA microarray can track the expression levels of thousands of genes simultaneously. Previous research has demonstrated that this technology can be useful in the classification ...
Yu Wang 0008, Igor V. Tetko, Mark A. Hall, Eibe Fr...
BMCBI
2005
131views more  BMCBI 2005»
13 years 7 months ago
Regularized Least Squares Cancer Classifiers from DNA microarray data
Background: The advent of the technology of DNA microarrays constitutes an epochal change in the classification and discovery of different types of cancer because the information ...
Nicola Ancona, Rosalia Maglietta, Annarita D'Addab...