The Protein Information Resource (PIR; http://wwwnbrf.georgetown.edu/pir/ ) supports research on molecular evolution, functional genomics, and computational biology by maintaining...
Winona C. Barker, John S. Garavelli, Daniel H. Haf...
Background: Genome sequence alignments form the basis of much research. Genome alignment depends on various mundane but critical choices, such as how to mask repeats and which sco...
Many non-coding RNA genes and cis-acting regulatory elements of mRNAs contain RNA secondary structures that are critical for their function. Such functional RNAs can be predicted ...
Background: A multiple sequence alignment (MSA) generated for a protein can be used to characterise residues by means of a statistical analysis of single columns. In addition to t...
Background: Although homology-based methods are among the most widely used methods for predicting the structure and function of proteins, the question as to whether interface sequ...