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» Pathway Analyst--Automated Metabolic Pathway Prediction
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BMCBI
2008
84views more  BMCBI 2008»
13 years 11 months ago
Prediction of specificity-determining residues for small-molecule kinase inhibitors
Background: Designing small-molecule kinase inhibitors with desirable selectivity profiles is a major challenge in drug discovery. A high-throughput screen for inhibitors of a giv...
Daniel R. Caffrey, Elizabeth A. Lunney, Deborah J....
SAC
2006
ACM
14 years 4 months ago
Protein classification using transductive learning on phylogenetic profiles
Phylogenetic profiles of proteins − strings of ones and zeros encoding respectively the presence and absence of proteins in a group of genomes − have recently been used to iden...
Roger A. Craig, Li Liao
BMCBI
2011
13 years 2 months ago
PRIN, a predicted rice interactome network
Background: Protein-protein interactions play a fundamental role in elucidating the molecular mechanisms of biomolecular function, signal transductions and metabolic pathways of l...
Haibin Gu, Pengcheng Zhu, Yinming Jiao, Yijun Meng...
BIBE
2010
IEEE
181views Bioinformatics» more  BIBE 2010»
13 years 12 months ago
Multi Level Clustering of Phylogenetic Profiles
The prediction of gene function from genome sequences is one of the main issues in Bioinformatics. Most computational approaches are based on the similarity between sequences to in...
Fotis E. Psomopoulos, Pericles A. Mitkas
BMCBI
2005
223views more  BMCBI 2005»
13 years 10 months ago
Bioinformatics approaches for cross-species liver cancer analysis based on microarray gene expression profiling
Background: The completion of the sequencing of human, mouse and rat genomes and knowledge of cross-species gene homologies enables studies of differential gene expression in anim...
Hong Fang, Weida Tong, Roger Perkins, Leming M. Sh...