We propose a framework for modeling sequence motifs based on the maximum entropy principle (MEP). We recommend approximating short sequence motif distributions with the maximum en...
Background: The dynamic motions of many proteins are central to their function. It therefore follows that the dynamic requirements of a protein are evolutionary constrained. In or...
Background: Genomic position (GP) files currently used in next-generation sequencing (NGS) studies are always difficult to manipulate due to their huge size and the lack of approp...
Executing large number of independent tasks or tasks that perform minimal inter-task communication in parallel is a common requirement in many domains. In this paper, we present o...
Xiaohong Qiu, Jaliya Ekanayake, Scott Beason, Thil...
Background: The most common application for the next-generation sequencing technologies is resequencing, where short reads from the genome of an individual are aligned to a refere...
Aakrosh Ratan, Yu Zhang, Vanessa M. Hayes, Stephan...