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BMCBI
2005
142views more  BMCBI 2005»
13 years 7 months ago
transAlign: using amino acids to facilitate the multiple alignment of protein-coding DNA sequences
Background: Alignments of homologous DNA sequences are crucial for comparative genomics and phylogenetic analysis. However, multiple alignment represents a computationally difficu...
Olaf R. P. Bininda-Emonds
BMCBI
2005
138views more  BMCBI 2005»
13 years 7 months ago
Detailed protein sequence alignment based on Spectral Similarity Score (SSS)
Background: The chemical property and biological function of a protein is a direct consequence of its primary structure. Several algorithms have been developed which determine ali...
Kshitiz Gupta, Dina Thomas, S. V. Vidya, K. V. Ven...
BMCBI
2005
132views more  BMCBI 2005»
13 years 7 months ago
Kalign - an accurate and fast multiple sequence alignment algorithm
Background: The alignment of multiple protein sequences is a fundamental step in the analysis of biological data. It has traditionally been applied to analyzing protein families f...
Timo Lassmann, Erik L. L. Sonnhammer
BMCBI
2005
198views more  BMCBI 2005»
13 years 7 months ago
Clustering protein sequences with a novel metric transformed from sequence similarity scores and sequence alignments with neural
Background: The sequencing of the human genome has enabled us to access a comprehensive list of genes (both experimental and predicted) for further analysis. While a majority of t...
Qicheng Ma, Gung-Wei Chirn, Richard Cai, Joseph D....
BMCBI
2005
97views more  BMCBI 2005»
13 years 7 months ago
Evolutionary distance estimation and fidelity of pair wise sequence alignment
Background: Evolutionary distances are a critical measure in comparative genomics and molecular evolutionary biology. A simulation study was used to examine the effect of alignmen...
Michael S. Rosenberg