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ISMB
1998
14 years 16 days ago
Phylogenetic Inference in Protein Superfamilies: Analysis of SH2 Domains
This workfocuses on the inference of evolutionary relationships in protein superfamilies, and the uses of these relationships to identify keypositions in the structure, to infer a...
Kimmen Sjölander
NAR
2006
120views more  NAR 2006»
13 years 11 months ago
TreeDomViewer: a tool for the visualization of phylogeny and protein domain structure
Phylogenetic analysis and examination of protein domains allow accurate genome annotation and are invaluable to study proteins and protein complex evolution. However, two sequence...
Blaise T. F. Alako, Daphne Rainey, Harm Nijveen, J...
BMCBI
2010
150views more  BMCBI 2010»
13 years 11 months ago
Evolutionary rates at codon sites may be used to align sequences and infer protein domain function
Background: Sequence alignments form part of many investigations in molecular biology, including the determination of phylogenetic relationships, the prediction of protein structu...
Pierre M. Durand, Scott Hazelhurst, Theresa L. Coe...
BMCBI
2006
134views more  BMCBI 2006»
13 years 11 months ago
A statistical score for assessing the quality of multiple sequence alignments
Background: Multiple sequence alignment is the foundation of many important applications in bioinformatics that aim at detecting functionally important regions, predicting protein...
Virpi Ahola, Tero Aittokallio, Mauno Vihinen, Esa ...
CANDC
2004
ACM
13 years 11 months ago
The iProClass integrated database for protein functional analysis
Increasingly, scientists have begun to tackle gene functions and other complex regulatory processes by studying organisms at the global scales for various levels of biological org...
Cathy H. Wu, Hongzhan Huang, Anastasia N. Nikolska...