168 search results - page 13 / 34 » Physics-based simulation of biological structures |
RECOMB
2001
Springer
14 years 2 days ago
2001
Springer
High-throughput, data-directed computational protocols for Structural Genomics (or Proteomics) are required in order to evaluate the protein products of genes for structure and fu...
BMCBI
2006
13 years 7 months ago
2006
Background: Successful realization of a "systems biology" approach to analyzing cells is a grand challenge for our understanding of life. However, current modeling appro...
BMCBI
2008
13 years 7 months ago
2008
Background: Protein structural alignment provides a fundamental basis for deriving principles of functional and evolutionary relationships. It is routinely used for structural cla...
CPHYSICS
2007
13 years 7 months ago
2007
Human big conductance Ca2+ - and voltage-gated K+ channels (hBK) are putative drug targets for cardiovascular, respiratory and urological diseases. Here we have used molecular sim...
BMCBI
2006
2006
Searching for interpretable rules for disease mutations: a simulated annealing bump hunting strategy
13 years 7 months ago
Background: Understanding how amino acid substitutions affect protein functions is critical for the study of proteins and their implications in diseases. Although methods have bee...