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BMCBI
2010
146views more  BMCBI 2010»
13 years 7 months ago
Genomic selection and complex trait prediction using a fast EM algorithm applied to genome-wide markers
Background: The information provided by dense genome-wide markers using high throughput technology is of considerable potential in human disease studies and livestock breeding pro...
Ross K. Shepherd, Theo H. E. Meuwissen, John A. Wo...
BMCBI
2010
151views more  BMCBI 2010»
13 years 7 months ago
CCRaVAT and QuTie - enabling analysis of rare variants in large-scale case control and quantitative trait association studies
Background: Genome-wide association studies have been successful in finding common variants influencing common traits. However, these associations only account for a fraction of t...
Robert Lawrence, Aaron G. Day-Williams, Katherine ...
JCB
2008
94views more  JCB 2008»
13 years 7 months ago
Prioritize and Select SNPs for Association Studies with Multi-Stage Designs
Large-scale whole genome association studies are increasingly common, due in large part to recent advances in genotyping technology. With this change in paradigm for genetic studi...
Jing Li
BMCBI
2011
13 years 2 months ago
SNP-based pathway enrichment analysis for genome-wide association studies
Background: Recently we have witnessed a surge of interest in using genome-wide association studies (GWAS) to discover the genetic basis of complex diseases. Many genetic variatio...
Lingjie Weng, Fabio Macciardi, Aravind Subramanian...
ICSE
2008
IEEE-ACM
14 years 8 months ago
Systematically refactoring inheritance to delegation in java
Because of the strong coupling of classes and the proliferation of unneeded class members induced by inheritance, the suggestion to use composition and delegation instead has beco...
Hannes Kegel, Friedrich Steimann