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BMCBI
2010
142views more  BMCBI 2010»
13 years 7 months ago
Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis
Background: High-throughput profiling of DNA methylation status of CpG islands is crucial to understand the epigenetic regulation of genes. The microarray-based Infinium methylati...
Pan Du, Xiao Zhang, Chiang-Ching Huang, Nadereh Ja...
BMCBI
2010
155views more  BMCBI 2010»
13 years 7 months ago
BrEPS: a flexible and automatic protocol to compute enzyme-specific sequence profiles for functional annotation
Background: Models for the simulation of metabolic networks require the accurate prediction of enzyme function. Based on a genomic sequence, enzymatic functions of gene products a...
Constantin Bannert, A. Welfle, C. aus dem Spring, ...
COGCOM
2010
107views more  COGCOM 2010»
13 years 7 months ago
Where to Look Next? Combining Static and Dynamic Proto-objects in a TVA-based Model of Visual Attention
To decide ``Where to look next ?'' is a central function of the attention system of humans, animals and robots. Control of attention depends on three factors, that is, lo...
Marco Wischnewski, Anna Belardinelli, Werner X. Sc...
BMCBI
2011
13 years 4 months ago
Accurate statistics for local sequence alignment with position-dependent scoring by rare-event sampling
Background: Molecular database search tools need statistical models to assess the significance for the resulting hits. In the classical approach one asks the question how probable...
Stefan Wolfsheimer, Inke Herms, Sven Rahmann, Alex...
BMCBI
2011
13 years 4 months ago
pROC: an open-source package for R and S+ to analyze and compare ROC curves
Background: Receiver operating characteristic (ROC) curves are useful tools to evaluate classifiers in biomedical and bioinformatics applications. However, conclusions are often r...
Xavier Robin, Natacha Turck, Alexandre Hainard, Na...