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BMCBI
2010
97views more  BMCBI 2010»
13 years 7 months ago
Kinome-wide interaction modelling using alignment-based and alignment-independent approaches for kinase description and linear a
Background: Protein kinases play crucial roles in cell growth, differentiation, and apoptosis. Abnormal function of protein kinases can lead to many serious diseases, such as canc...
Maris Lapinsh, Jarl E. S. Wikberg
BIBE
2009
IEEE
185views Bioinformatics» more  BIBE 2009»
14 years 22 days ago
Anomaly-free Prediction of Gene Ontology Annotations Using Bayesian Networks
Gene and protein structural and functional annotations expressed through controlled terminologies and ontologies are paramount especially for the aim of inferring new biomedical k...
Marco Tagliasacchi, Marco Masseroli
ICSM
2008
IEEE
14 years 2 months ago
Supporting software evolution analysis with historical dependencies and defect information
More than 90% of the cost of software is due to maintenance and evolution. Understanding the evolution of large software systems is a complex problem, which requires the use of va...
Marco D'Ambros
BMCBI
2008
147views more  BMCBI 2008»
13 years 7 months ago
Transmembrane helix prediction using amino acid property features and latent semantic analysis
Background: Prediction of transmembrane (TM) helices by statistical methods suffers from lack of sufficient training data. Current best methods use hundreds or even thousands of f...
Madhavi Ganapathiraju, Narayanas Balakrishnan, Raj...
BMCBI
2010
121views more  BMCBI 2010»
13 years 7 months ago
Knowledge-based annotation of small molecule binding sites in proteins
Background: The study of protein-small molecule interactions is vital for understanding protein function and for practical applications in drug discovery. To benefit from the rapi...
Ratna R. Thangudu, Manoj Tyagi, Benjamin A. Shoema...