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BMCBI
2011
13 years 2 months ago
DoBo: Protein domain boundary prediction by integrating evolutionary signals and machine learning
Background: Accurate identification of protein domain boundaries is useful for protein structure determination and prediction. However, predicting protein domain boundaries from a...
Jesse Eickholt, Xin Deng, Jianlin Cheng
BMCBI
2011
13 years 2 months ago
Multithreaded comparative RNA secondary structure prediction using stochastic context-free grammars
Background: The prediction of the structure of large RNAs remains a particular challenge in bioinformatics, due to the computational complexity and low levels of accuracy of state...
Zsuzsanna Sukosd, Bjarne Knudsen, Morten Vaerum, J...
BIRD
2007
Springer
107views Bioinformatics» more  BIRD 2007»
14 years 1 months ago
Prediction of Structurally-Determined Coiled-Coil Domains with Hidden Markov Models
The coiled-coil protein domain is a widespread structural motif known to be involved in a wealth of key interactions in cells and organisms. Coiled-coil recognition and prediction ...
Piero Fariselli, Daniele Molinini, Rita Casadio, A...
IJCAI
2007
13 years 9 months ago
r-grams: Relational Grams
We introduce relational grams (r-grams). They upgrade n-grams for modeling relational sequences of atoms. As n-grams, r-grams are based on smoothed n-th order Markov chains. Smoot...
Niels Landwehr, Luc De Raedt
BMCBI
2006
152views more  BMCBI 2006»
13 years 7 months ago
Predicting deleterious nsSNPs: an analysis of sequence and structural attributes
Background: There has been an explosion in the number of single nucleotide polymorphisms (SNPs) within public databases. In this study we focused on non-synonymous protein coding ...
Richard J. B. Dobson, Patricia B. Munroe, Mark J. ...