Background: We have previously described an approach to predicting the substrate specificity of serine-threonine protein kinases. The method, named Predikin, identifies key conser...
Neil F. W. Saunders, Ross I. Brinkworth, Thomas Hu...
Protein structure similarity and classification methods have many applications in protein function prediction and associated fields (e.g. drug discovery). In this paper, we propose...
Background: Protein folding rate is an important property of a protein. Predicting protein folding rate is useful for understanding protein folding process and guiding protein des...
Background: Many structural properties such as solvent accessibility, dihedral angles and helix-helix contacts can be assigned to each residue in a membrane protein. Independent s...
Background: Designing small-molecule kinase inhibitors with desirable selectivity profiles is a major challenge in drug discovery. A high-throughput screen for inhibitors of a giv...
Daniel R. Caffrey, Elizabeth A. Lunney, Deborah J....