We describe SVMotif, a support vector machine-based learning algorithm for identification of cellular DNA transcription factor (TF) motifs extrapolated from known TF-gene interact...
Mark A. Kon, Yue Fan, Dustin T. Holloway, Charles ...
Background: Many dimeric protein complexes bind cooperatively to families of bipartite nucleic acid sequence elements, which consist of pairs of conserved half-site sequences sepa...
Background: High throughput signature sequencing holds many promises, one of which is the ready identification of in vivo transcription factor binding sites, histone modifications...
Background: A complete understanding of the regulatory mechanisms of gene expression is the next important issue of genomics. Many bioinformaticians have developed methods and alg...
Background: The binding of regulatory proteins to their specific DNA targets determines the accurate expression of the neighboring genes. The in silico prediction of new binding s...