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BMCBI
2010
99views more  BMCBI 2010»
13 years 9 months ago
Different effects of the probe summarization algorithms PLIER and RMA on high-level analysis of Affymetrix exon arrays
Background: Alternative splicing is an important mechanism that increases protein diversity and functionality in higher eukaryotes. Affymetrix exon arrays are a commercialized pla...
Yi Qu, Fei He, Yuchen Chen
BMCBI
2010
109views more  BMCBI 2010»
13 years 9 months ago
Free energy estimation of short DNA duplex hybridizations
Background: Estimation of DNA duplex hybridization free energy is widely used for predicting cross-hybridizations in DNA computing and microarray experiments. A number of software...
Dan C. Tulpan, Mirela Andronescu, Serge Leger
BMCBI
2010
191views more  BMCBI 2010»
13 years 9 months ago
BiGG: a Biochemical Genetic and Genomic knowledgebase of large scale metabolic reconstructions
Background: Genome-scale metabolic reconstructions under the Constraint Based Reconstruction and Analysis (COBRA) framework are valuable tools for analyzing the metabolic capabili...
Jan Schellenberger, Junyoung O. Park, Tom M. Conra...
BMCBI
2008
173views more  BMCBI 2008»
13 years 9 months ago
Extraction of semantic biomedical relations from text using conditional random fields
Background: The increasing amount of published literature in biomedicine represents an immense source of knowledge, which can only efficiently be accessed by a new generation of a...
Markus Bundschus, Mathäus Dejori, Martin Stet...
BMCBI
2010
138views more  BMCBI 2010»
13 years 9 months ago
Sigma-2: Multiple sequence alignment of non-coding DNA via an evolutionary model
Background: While most multiple sequence alignment programs expect that all or most of their input is known to be homologous, and penalise insertions and deletions, this is not a ...
Gayathri Jayaraman, Rahul Siddharthan