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SIAMJO
2010
83views more  SIAMJO 2010»
13 years 6 months ago
The Lifted Newton Method and Its Application in Optimization
Abstract. We present a new “lifting” approach for the solution of nonlinear optimization problems (NLPs) that have objective and constraint functions with intermediate variable...
Jan Albersmeyer, Moritz Diehl
BMCBI
2011
13 years 2 months ago
A theoretical entropy score as a single value to express inhibitor selectivity
Background: Designing maximally selective ligands that act on individual targets is the dominant paradigm in drug discovery. Poor selectivity can underlie toxicity and side effect...
Joost C. M. Uitdehaag, Guido J. R. Zaman
KDD
2012
ACM
200views Data Mining» more  KDD 2012»
11 years 10 months ago
Vertex neighborhoods, low conductance cuts, and good seeds for local community methods
The communities of a social network are sets of vertices with more connections inside the set than outside. We theoretically demonstrate that two commonly observed properties of s...
David F. Gleich, C. Seshadhri
ICSE
2012
IEEE-ACM
11 years 10 months ago
WitchDoctor: IDE support for real-time auto-completion of refactorings
—Integrated Development Environments (IDEs) have come to perform a wide variety of tasks on behalf of the programmer, refactoring being a classic example. These operations have u...
Stephen R. Foster, William G. Griswold, Sorin Lern...
ALT
2004
Springer
14 years 4 months ago
On Kernels, Margins, and Low-Dimensional Mappings
Kernel functions are typically viewed as providing an implicit mapping of points into a high-dimensional space, with the ability to gain much of the power of that space without inc...
Maria-Florina Balcan, Avrim Blum, Santosh Vempala