A number of medically important disease-causing bacteria (collectively called Gram-negative bacteria) are noted for the extra "outer" membrane that surrounds their cell....
Rong She, Fei Chen 0002, Ke Wang, Martin Ester, Je...
Position-specific scoring matrices have been used extensively to recognize highly conserved protein regions. We present a method for accelerating these searches using a suffix tre...
Protein sequence alignments are more reliable the shorter the evolutionary distance. Here, we align distantly related proteins using many closely spaced intermediate sequences as ...
Randomized search heuristics, among them randomized local search and evolutionary algorithms, are applied to problems whose structure is not well understood, as well as to problems...
Background: Local structures of target mRNAs play a significant role in determining the efficacies of antisense oligonucleotides (ODNs), but some structure-based target site selec...