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BMCBI
2010
144views more  BMCBI 2010»
13 years 10 months ago
Super-sparse principal component analyses for high-throughput genomic data
Background: Principal component analysis (PCA) has gained popularity as a method for the analysis of highdimensional genomic data. However, it is often difficult to interpret the ...
Donghwan Lee, Woojoo Lee, Youngjo Lee, Yudi Pawita...
BMCBI
2010
130views more  BMCBI 2010»
13 years 10 months ago
The behaviour of random forest permutation-based variable importance measures under predictor correlation
Background: Random forests (RF) have been increasingly used in applications such as genome-wide association and microarray studies where predictor correlation is frequently observ...
Kristin K. Nicodemus, James D. Malley, Carolin Str...
BMCBI
2010
95views more  BMCBI 2010»
13 years 10 months ago
Quantifying the relationship between sequence and three-dimensional structure conservation in RNA
Background: In recent years, the number of available RNA structures has rapidly grown reflecting the increased interest on RNA biology. Similarly to the studies carried out two de...
Emidio Capriotti, Marc A. Martí-Renom
BMCBI
2010
118views more  BMCBI 2010»
13 years 10 months ago
Towards realistic benchmarks for multiple alignments of non-coding sequences
Background: With the continued development of new computational tools for multiple sequence alignment, it is necessary today to develop benchmarks that aid the selection of the mo...
Jaebum Kim, Saurabh Sinha
BMCBI
2010
120views more  BMCBI 2010»
13 years 10 months ago
Modeling expression quantitative trait loci in data combining ethnic populations
Background: Combining data from different ethnic populations in a study can increase efficacy of methods designed to identify expression quantitative trait loci (eQTL) compared to...
Ching-Lin Hsiao, Ie-Bin Lian, Ai-Ru Hsieh, Cathy S...