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» Representation for Discovery of Protein Motifs
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BMCBI
2005
106views more  BMCBI 2005»
13 years 7 months ago
A multistep bioinformatic approach detects putative regulatory elements in gene promoters
Background: Searching for approximate patterns in large promoter sequences frequently produces an exceedingly high numbers of results. Our aim was to exploit biological knowledge ...
Stefania Bortoluzzi, Alessandro Coppe, Andrea Biso...
GECCO
2007
Springer
258views Optimization» more  GECCO 2007»
13 years 11 months ago
TFBS identification by position- and consensus-led genetic algorithm with local filtering
Identification of Transcription Factor Binding Site (TFBS) motifs in multiple DNA upstream sequences is important in understanding the mechanism of gene regulation. This identific...
Tak-Ming Chan, Kwong-Sak Leung, Kin-Hong Lee
BMCBI
2008
208views more  BMCBI 2008»
13 years 7 months ago
GraphFind: enhancing graph searching by low support data mining techniques
Background: Biomedical and chemical databases are large and rapidly growing in size. Graphs naturally model such kinds of data. To fully exploit the wealth of information in these...
Alfredo Ferro, Rosalba Giugno, Misael Mongiov&igra...
TCBB
2010
80views more  TCBB 2010»
13 years 6 months ago
On the Importance of Comprehensible Classification Models for Protein Function Prediction
—The literature on protein function prediction is currently dominated by works aimed at maximizing predictive accuracy, ignoring the important issues of validation and interpreta...
Alex Alves Freitas, Daniela Wieser, Rolf Apweiler
BMCBI
2005
130views more  BMCBI 2005»
13 years 7 months ago
Some statistical properties of regulatory DNA sequences, and their use in predicting regulatory regions in the Drosophila genome
Background: This paper addresses the problem of recognising DNA cis-regulatory modules which are located far from genes. Experimental procedures for this are slow and costly, and ...
Irina I. Abnizova, Rene te Boekhorst, Klaudia Walt...