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BMCBI
2005
118views more  BMCBI 2005»
13 years 9 months ago
Variation in structural location and amino acid conservation of functional sites in protein domain families
Background: The functional sites of a protein present important information for determining its cellular function and are fundamental in drug design. Accordingly, accurate methods...
Birgit Pils, Richard R. Copley, Jörg Schultz
BMCBI
2005
100views more  BMCBI 2005»
13 years 9 months ago
Scoredist: A simple and robust protein sequence distance estimator
Background: Distance-based methods are popular for reconstructing evolutionary trees thanks to their speed and generality. A number of methods exist for estimating distances from ...
Erik L. L. Sonnhammer, Volker Hollich
BMCBI
2005
131views more  BMCBI 2005»
13 years 9 months ago
Regularized Least Squares Cancer Classifiers from DNA microarray data
Background: The advent of the technology of DNA microarrays constitutes an epochal change in the classification and discovery of different types of cancer because the information ...
Nicola Ancona, Rosalia Maglietta, Annarita D'Addab...
JETAI
2007
131views more  JETAI 2007»
13 years 9 months ago
A computational architecture for heterogeneous reasoning
Reasoning, problem solving, indeed the general process of acquiring knowledge, is not an isolated, homogenous affair involving a one agent using a single form of representation, b...
Dave Barker-Plummer, John Etchemendy
CCR
2005
131views more  CCR 2005»
13 years 9 months ago
A clean slate 4D approach to network control and management
Today's data networks are surprisingly fragile and difficult to manage. We argue that the root of these problems lies in the complexity of the control and management planes--...
Albert G. Greenberg, Gísli Hjálmt&ya...
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