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BMCBI
2011
13 years 1 months ago
GPCR-SSFE: A comprehensive database of G-protein-coupled receptor template predictions and homology models
Background: G protein-coupled receptors (GPCRs) transduce a wide variety of extracellular signals to within the cell and therefore have a key role in regulating cell activity and ...
Catherine L. Worth, Annika Kreuchwig, Gunnar Klein...
BMCBI
2011
13 years 1 months ago
Conotoxin Protein Classification Using Free Scores of Words and Support Vector Machines
Background: Conotoxin has been proven to be effective in drug design and could be used to treat various disorders such as schizophrenia, neuromuscular disorders and chronic pain. ...
Nazar Zaki, Stefan Wolfsheimer, Grégory Nue...
BMCBI
2011
13 years 1 months ago
NeurphologyJ: an automatic neuronal morphology quantification method and its application in pharmacological discovery
Background: Automatic quantification of neuronal morphology from images of fluorescence microscopy plays an increasingly important role in high-content screenings. However, there ...
Shinn-Ying Ho, Chih-Yuan Chao, Hui-Ling Huang, Tza...
BMCBI
2011
13 years 1 months ago
In-silico prediction of disorder content using hybrid sequence representation
Background: Intrinsically disordered proteins play important roles in various cellular activities and their prevalence was implicated in a number of human diseases. The knowledge ...
Marcin J. Mizianty, Tuo Zhang, Bin Xue, Yaoqi Zhou...
BMCBI
2011
13 years 1 months ago
Reconstructing genome-wide regulatory network of E. coli using transcriptome data and predicted transcription factor activities
Background: Gene regulatory networks play essential roles in living organisms to control growth, keep internal metabolism running and respond to external environmental changes. Un...
Yao Fu, Laura R. Jarboe, Julie A. Dickerson