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ICMLA
2008
13 years 10 months ago
Comprehensible Models for Predicting Molecular Interaction with Heart-Regulating Genes
When using machine learning for in silico modeling, the goal is normally to obtain highly accurate predictive models. Often, however, models should also bring insights into intere...
Cecilia Sönströd, Ulf Johansson, Ulf Nor...
BMCBI
2006
64views more  BMCBI 2006»
13 years 9 months ago
In silico modelling of hormone response elements
Background: An important step in understanding the conditions that specify gene expression is the recognition of gene regulatory elements. Due to high diversity of different types...
Maria Stepanova, Feng Lin, Valerie C.-L. Lin
BMCBI
2010
154views more  BMCBI 2010»
13 years 6 months ago
Knowledge-based matrix factorization temporally resolves the cellular responses to IL-6 stimulation
Background: External stimulations of cells by hormones, cytokines or growth factors activate signal transduction pathways that subsequently induce a re-arrangement of cellular gen...
Andreas Kowarsch, Florian Blöchl, Sebastian B...
ISBRA
2010
Springer
13 years 7 months ago
Analysis of Gene Interactions Using Restricted Boolean Networks and Time-Series Data
A popular model for gene regulatory networks is the Boolean network model. In this paper, we propose an algorithm to perform an analysis of gene regulatory interactions using the B...
Carlos H. A. Higa, Vitor H. P. Louzada, Ronaldo Fu...
BMCBI
2010
118views more  BMCBI 2010»
13 years 9 months ago
Bacillus anthracis genome organization in light of whole transcriptome sequencing
Emerging knowledge of whole prokaryotic transcriptomes could validate a number of theoretical concepts introduced in the early days of genomics. What are the rules connecting gene...
Jeffrey Martin, Wenhan Zhu, Karla D. Passalacqua, ...