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» Scoring functions and enrichment: a case study on Hsp90
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BMCBI
2010
126views more  BMCBI 2010»
13 years 7 months ago
A boosting method for maximizing the partial area under the ROC curve
Background: The receiver operating characteristic (ROC) curve is a fundamental tool to assess the discriminant performance for not only a single marker but also a score function c...
Osamu Komori, Shinto Eguchi
DAWAK
2008
Springer
13 years 9 months ago
UML-Based Modeling for What-If Analysis
In order to be able to evaluate beforehand the impact of a strategical or tactical move, decision makers need reliable previsional systems. What-if analysis satisfies this need by ...
Matteo Golfarelli, Stefano Rizzi
BMCBI
2006
147views more  BMCBI 2006»
13 years 7 months ago
QPath: a method for querying pathways in a protein-protein interaction network
Background: Sequence comparison is one of the most prominent tools in biological research, and is instrumental in studying gene function and evolution. The rapid development of hi...
Tomer Shlomi, Daniel Segal, Eytan Ruppin, Roded Sh...
SIGMOD
2009
ACM
137views Database» more  SIGMOD 2009»
14 years 7 months ago
Robust and efficient algorithms for rank join evaluation
In the rank join problem we are given a relational join R1 1 R2 and a function that assigns numeric scores to the join tuples, and the goal is to return the tuples with the highes...
Jonathan Finger, Neoklis Polyzotis
BMCBI
2010
116views more  BMCBI 2010»
13 years 7 months ago
Optimization algorithms for functional deimmunization of therapeutic proteins
Background: To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the ...
Andrew S. Parker, Wei Zheng, Karl E. Griswold, Chr...