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BMCBI
2010
101views more  BMCBI 2010»
13 years 8 months ago
Enrichment of homologs in insignificant BLAST hits by co-complex network alignment
Background: Homology is a crucial concept in comparative genomics. The algorithm probably most widely used for homology detection in comparative genomics, is BLAST. Usually a stri...
Like Fokkens, Sandra M. C. Botelho, Jos Boekhorst,...
BMCBI
2010
125views more  BMCBI 2010»
13 years 8 months ago
In-silico prediction of blood-secretory human proteins using a ranking algorithm
Background: Computational identification of blood-secretory proteins, especially proteins with differentially expressed genes in diseased tissues, can provide highly useful inform...
Qi Liu, Juan Cui, Qiang Yang, Ying Xu
BMCBI
2010
155views more  BMCBI 2010»
13 years 8 months ago
BISMA - Fast and accurate bisulfite sequencing data analysis of individual clones from unique and repetitive sequences
Background: Bisulfite sequencing is a popular method to analyze DNA methylation patterns at high resolution. A region of interest is targeted by PCR and about 20-50 subcloned DNA ...
Christian Rohde, Yingying Zhang, Richard Reinhardt...
BMCBI
2010
152views more  BMCBI 2010»
13 years 8 months ago
A high-throughput de novo sequencing approach for shotgun proteomics using high-resolution tandem mass spectrometry
Background: High-resolution tandem mass spectra can now be readily acquired with hybrid instruments, such as LTQ-Orbitrap and LTQ-FT, in high-throughput shotgun proteomics workflo...
Chongle Pan, Byung-Hoon Park, William H. McDonald,...
BMCBI
2010
277views more  BMCBI 2010»
13 years 8 months ago
PCA2GO: a new multivariate statistics based method to identify highly expressed GO-Terms
Background: Several tools have been developed to explore and search Gene Ontology (GO) databases allowing efficient GO enrichment analysis and GO tree visualization. Nevertheless,...
Marc Bruckskotten, Mario Looso, Franz Cemic, Anne ...