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144
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BMCBI
2004
115views more  BMCBI 2004»
15 years 3 months ago
An SVD-based comparison of nine whole eukaryotic genomes supports a coelomate rather than ecdysozoan lineage
Background: Eukaryotic whole genome sequences are accumulating at an impressive rate. Effective methods for comparing multiple whole eukaryotic genomes on a large scale are needed...
Gary W. Stuart, Michael W. Berry
151
Voted
BMCBI
2004
128views more  BMCBI 2004»
15 years 3 months ago
Comparing transformation methods for DNA microarray data
Background: When DNA microarray data are used for gene clustering, genotype/phenotype correlation studies, or tissue classification the signal intensities are usually transformed ...
Helene H. Thygesen, Aeilko H. Zwinderman
134
Voted
BMCBI
2004
153views more  BMCBI 2004»
15 years 3 months ago
Computational protein biomarker prediction: a case study for prostate cancer
Background: Recent technological advances in mass spectrometry pose challenges in computational mathematics and statistics to process the mass spectral data into predictive models...
Michael Wagner, Dayanand N. Naik, Alex Pothen, Sri...
139
Voted
BMCBI
2004
132views more  BMCBI 2004»
15 years 3 months ago
Two-stage normalization using background intensities in cDNA microarray data
Background: In the microarray experiment, many undesirable systematic variations are commonly observed. Normalization is the process of removing such variation that affects the me...
Dankyu Yoon, Sung-Gon Yi, Ju-Han Kim, Taesung Park
119
Voted
CANDC
2004
ACM
15 years 3 months ago
Phylogenetic distribution of DNA-binding transcription factors in bacteria and archaea
We have addressed the distribution and abundance of 75 transcription factor (TF) families in complete genomes from 90 different bacterial and archaeal species. We found that the p...
Ernesto Pérez-Rueda, Julio Collado-Vides, L...
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