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BMCBI
2010
110views more  BMCBI 2010»
13 years 7 months ago
Discovering local patterns of co - evolution: computational aspects and biological examples
Background: Co-evolution is the process in which two (or more) sets of orthologs exhibit a similar or correlative pattern of evolution. Co-evolution is a powerful way to learn abo...
Tamir Tuller, Yifat Felder, Martin Kupiec
BMCBI
2010
89views more  BMCBI 2010»
13 years 7 months ago
Spatial normalization improves the quality of genotype calling for Affymetrix SNP 6.0 arrays
Background: Microarray measurements are susceptible to a variety of experimental artifacts, some of which give rise to systematic biases that are spatially dependent in a unique w...
High-Seng Chai, Terry M. Therneau, Kent R. Bailey,...
BMCBI
2010
160views more  BMCBI 2010»
13 years 7 months ago
Identification of functional hubs and modules by converting interactome networks into hierarchical ordering of proteins
Background: Protein-protein interactions play a key role in biological processes of proteins within a cell. Recent high-throughput techniques have generated protein-protein intera...
Young-Rae Cho, Aidong Zhang
BMCBI
2010
156views more  BMCBI 2010»
13 years 7 months ago
Comparative classification of species and the study of pathway evolution based on the alignment of metabolic pathways
Background: Pathways provide topical descriptions of cellular circuitry. Comparing analogous pathways reveals intricate insights into individual functional differences among speci...
Adi Mano, Tamir Tuller, Oded Béjà, R...
BMCBI
2010
121views more  BMCBI 2010»
13 years 7 months ago
Knowledge-based annotation of small molecule binding sites in proteins
Background: The study of protein-small molecule interactions is vital for understanding protein function and for practical applications in drug discovery. To benefit from the rapi...
Ratna R. Thangudu, Manoj Tyagi, Benjamin A. Shoema...
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