Background: Protein sequence clustering has been widely used as a part of the analysis of protein structure and function. In most cases single linkage or graph-based clustering al...
Yonghui Chen, Kevin D. Reilly, Alan P. Sprague, Zh...
Background: Protein sequence motifs are by definition short fragments of conserved amino acids, often associated with a specific function. Accordingly protein sequence profiles de...
Jan Hummel, Nima Keshvari, Wolfram Weckwerth, Joac...
Background: Expression microarrays are increasingly used to characterize environmental responses and hostparasite interactions for many different organisms. Probe selection for cD...
Yian A. Chen, David J. Mckillen, Shuyuan Wu, Matth...
Quantification of selective pressures on regulatory sequences is a central question in studying the evolution of gene regulatory networks. Previous methods focus primarily on sing...
Background: Many dimeric protein complexes bind cooperatively to families of bipartite nucleic acid sequence elements, which consist of pairs of conserved half-site sequences sepa...