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» Statistical Analysis of Long-Range Interactions in Proteins
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JAMIA
2011
94views more  JAMIA 2011»
12 years 10 months ago
Protein-network modeling of prostate cancer gene signatures reveals essential pathways in disease recurrence
Objective Uncovering the dominant molecular deregulation among the multitude of pathways implicated in aggressive prostate cancer is essential to intelligently developing targeted...
James L. Chen, Jianrong Li, Walter M. Stadler, Yve...
BMCBI
2010
102views more  BMCBI 2010»
13 years 7 months ago
Quantized correlation coefficient for measuring reproducibility of ChIP-chip data
Background: Chromatin immunoprecipitation followed by microarray hybridization (ChIP-chip) is used to study protein-DNA interactions and histone modifications on a genome-scale. T...
Shouyong Peng, Mitzi I. Kuroda, Peter J. Park
BMCBI
2004
150views more  BMCBI 2004»
13 years 7 months ago
Graph-based iterative Group Analysis enhances microarray interpretation
Background: One of the most time-consuming tasks after performing a gene expression experiment is the biological interpretation of the results by identifying physiologically impor...
Rainer Breitling, Anna Amtmann, Pawel Herzyk
BMCBI
2010
154views more  BMCBI 2010»
13 years 7 months ago
An eScience-Bayes strategy for analyzing omics data
Background: The omics fields promise to revolutionize our understanding of biology and biomedicine. However, their potential is compromised by the challenge to analyze the huge da...
Martin Eklund, Ola Spjuth, Jarl E. S. Wikberg
CANDC
2004
ACM
13 years 7 months ago
The difficult interpretation of transcriptome data: the case of the GATC regulatory network
Genomic analyses on part of Escherichia coli's chromosome had suggested the existence of a GATC regulated network. This has recently been confirmed through a transcriptome an...
Alessandra Riva, Marie-Odile Delorme, Tony Chevali...