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BMCBI
2008
176views more  BMCBI 2008»
13 years 7 months ago
H2r: Identification of evolutionary important residues by means of an entropy based analysis of multiple sequence alignments
Background: A multiple sequence alignment (MSA) generated for a protein can be used to characterise residues by means of a statistical analysis of single columns. In addition to t...
Rainer Merkl, Matthias Zwick
SP
2008
IEEE
159views Security Privacy» more  SP 2008»
13 years 7 months ago
Inferring neuronal network connectivity from spike data: A temporal data mining approach
Abstract. Understanding the functioning of a neural system in terms of its underlying circuitry is an important problem in neuroscience. Recent developments in electrophysiology an...
Debprakash Patnaik, P. S. Sastry, K. P. Unnikrishn...
ISVD
2007
IEEE
14 years 1 months ago
Decoy Discrimination Using Contact Potentials Based on Delaunay Tessellation of Hydrated Proteins
Three strategies are presented for developing a knowledge-based statistical contact potential from computationally hydrated proteins that may be useful in studies of protein foldi...
Gregory M. Reck, Iosif I. Vaisman
BMCBI
2010
115views more  BMCBI 2010»
13 years 7 months ago
CONAN: copy number variation analysis software for genome-wide association studies
Background: Genome-wide association studies (GWAS) based on single nucleotide polymorphisms (SNPs) revolutionized our perception of the genetic regulation of complex traits and di...
Lukas Forer, Sebastian Schönherr, Hansi Wei&s...
BMCBI
2006
137views more  BMCBI 2006»
13 years 7 months ago
A maximum likelihood framework for protein design
Background: The aim of protein design is to predict amino-acid sequences compatible with a given target structure. Traditionally envisioned as a purely thermodynamic question, thi...
Claudia L. Kleinman, Nicolas Rodrigue, Céci...