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» Statistical analysis of domains in interacting protein pairs
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BMCBI
2010
137views more  BMCBI 2010»
13 years 4 months ago
The ancient history of the structure of ribonuclease P and the early origins of Archaea
Background: Ribonuclease P is an ancient endonuclease that cleaves precursor tRNA and generally consists of a catalytic RNA subunit (RPR) and one or more proteins (RPPs). It repre...
Feng-Jie Sun, Gustavo Caetano-Anollés
NIPS
1998
13 years 10 months ago
Learning from Dyadic Data
Dyadic data refers to a domain with two nite sets of objects in which observations are made for dyads, i.e., pairs with one element from either set. This type of data arises natur...
Thomas Hofmann, Jan Puzicha, Michael I. Jordan
BMCBI
2008
145views more  BMCBI 2008»
13 years 9 months ago
The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction
Background: Amino acids responsible for structure, core function or specificity may be inferred from multiple protein sequence alignments where a limited set of residue types are ...
Jonathan R. Manning, Emily R. Jefferson, Geoffrey ...
BMCBI
2010
144views more  BMCBI 2010»
13 years 9 months ago
Identifying overrepresented concepts in gene lists from literature: a statistical approach based on Poisson mixture model
Background: Large-scale genomic studies often identify large gene lists, for example, the genes sharing the same expression patterns. The interpretation of these gene lists is gen...
Xin He, Moushumi Sen Sarma, Xu Ling, Brant W. Chee...
NIPS
2008
13 years 10 months ago
Mixed Membership Stochastic Blockmodels
Consider data consisting of pairwise measurements, such as presence or absence of links between pairs of objects. These data arise, for instance, in the analysis of protein intera...
Edoardo Airoldi, David M. Blei, Stephen E. Fienber...