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» Stochastic pairwise alignments
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RECOMB
2005
Springer
14 years 8 months ago
Pairwise Local Alignment of Protein Interaction Networks Guided by Models of Evolution
Abstract. With ever increasing amount of available data on protein-protein interaction (PPI) networks and research revealing that these networks evolve at a modular level, discover...
Mehmet Koyutürk, Ananth Grama, Wojciech Szpan...
TCBB
2008
138views more  TCBB 2008»
13 years 7 months ago
PairProSVM: Protein Subcellular Localization Based on Local Pairwise Profile Alignment and SVM
The subcellular locations of proteins are important functional annotations. An effective and reliable subcellular localization method is necessary for proteomics research. This pap...
Man-Wai Mak, Jian Guo, Sun-Yuan Kung
BMCBI
2008
83views more  BMCBI 2008»
13 years 7 months ago
An efficient genetic algorithm for structural RNA pairwise alignment and its application to non-coding RNA discovery in yeast
Background: Aligning RNA sequences with low sequence identity has been a challenging problem since such a computation essentially needs an algorithm with high complexities for tak...
Akito Taneda
BMCBI
2008
149views more  BMCBI 2008»
13 years 7 months ago
Evolution of biological sequences implies an extreme value distribution of type I for both global and local pairwise alignment s
Background: Confidence in pairwise alignments of biological sequences, obtained by various methods such as Blast or Smith-Waterman, is critical for automatic analyses of genomic d...
Olivier Bastien, Eric Maréchal
WABI
2009
Springer
128views Bioinformatics» more  WABI 2009»
14 years 2 months ago
A General Framework for Local Pairwise Alignment Statistics with Gaps
We present a novel dynamic programming framework that allows one to compute tight upper bounds for the p-values of gapped local alignments in pseudo–polynomial time. Our algorith...
Pasi Rastas