In this work we present a new methodology for structure and parameter estimation in cell systems biology modelling. Our modelling framework is based on P systems, an unconl comput...
Understanding the self-regulatory mechanisms controlling the spatial and temporal structure of multicellular organisms represents one of the major challenges in molecular biology. ...
Biologically focused, agent-based models need many parameters in order to simulate system dynamics. It is often essential to explore the consequences of many parameter vectors bef...
— This paper presents two novel estimation methods that are designed to enhance our ability of observing, positioning, and physically transforming the objects and/or biological s...
Hakan Bilen, Muhammet A. Hocaoglu, Eray A. Baran, ...
Many useful applications of simulation in computational cell biology, e.g. kinetic parameter estimation, Metabolic Control Analysis (MCA), and bifurcation analysis, require a large...