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BMCBI
2010
106views more  BMCBI 2010»
13 years 7 months ago
A computational evaluation of over-representation of regulatory motifs in the promoter regions of differentially expressed genes
Background: Observed co-expression of a group of genes is frequently attributed to co-regulation by shared transcription factors. This assumption has led to the hypothesis that pr...
Guofeng Meng, Axel Mosig, Martin Vingron
KDD
2006
ACM
156views Data Mining» more  KDD 2006»
14 years 7 months ago
Discovering significant OPSM subspace clusters in massive gene expression data
Order-preserving submatrixes (OPSMs) have been accepted as a biologically meaningful subspace cluster model, capturing the general tendency of gene expressions across a subset of ...
Byron J. Gao, Obi L. Griffith, Martin Ester, Steve...
BMCBI
2005
97views more  BMCBI 2005»
13 years 7 months ago
Phylogenetic reconstruction of ancestral character states for gene expression and mRNA splicing data
Background: As genomes evolve after speciation, gene content, coding sequence, gene expression, and splicing all diverge with time from ancestors with close relatives. A minimum e...
Roald Rossnes, Ingvar Eidhammer, David A. Liberles
BMCBI
2006
153views more  BMCBI 2006»
13 years 7 months ago
Cancer diagnosis marker extraction for soft tissue sarcomas based on gene expression profiling data by using projective adaptive
Background: Recent advances in genome technologies have provided an excellent opportunity to determine the complete biological characteristics of neoplastic tissues, resulting in ...
Hiro Takahashi, Takeshi Nemoto, Teruhiko Yoshida, ...
BMCBI
2005
113views more  BMCBI 2005»
13 years 7 months ago
Systematic survey reveals general applicability of "guilt-by-association" within gene coexpression networks
Background: Biological processes are carried out by coordinated modules of interacting molecules. As clustering methods demonstrate that genes with similar expression display incr...
Cecily J. Wolfe, Isaac S. Kohane, Atul J. Butte